Ical review of the manuscript, and performed the transurethral resection of > 자유게시판

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Ical review of the manuscript, and performed the transurethral resection of the tumors. EP contributed to the preparation of the images and the review of the literature. AG was present in the operation theater during the nephroureterectomy. KP performed the pathologic examination of the specimens. DM performed the nephroureterectomy and a critical review of the manuscript. All the authors approve the content of the manuscript.Do you have a case to share?Submit your case report today ?Rapid peer review ?Fast publication ?PubMed indexing ?Inclusion in Cases Database Any patient, any case, can teach us something
Johansson et al. Arthritis Research Therapy (2016) 18:127 DOI 10.1186/s13075-016-1031-RESEARCH ARTICLEOpen AccessAntibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritisLinda Johansson2, Federico Pratesi1, Mikael Brink2, Lisbeth lestig2, Claudia D'Amato1, Debora Bartaloni1, Paola Migliorini1 and Solbritt Rantap -Dahlqvist2*AbstractBackground: Anti-citrullinated-peptide antibodies (ACPA) have been detected in individuals with developing rheumatoid arthritis (RA) before the onset of symptom, with an initially limited spectrum of reactivities that gradually broadens. The aim was to analyze the evolution of ACPA response pre-dating symptom onset, using four selected citrullinated exogenous and endogenous antigens. Methods: A cohort of 521 individuals sampled before symptoms of RA appeared and 272 population controls were identified from the Biobank of Northern Sweden; 241 samples from patients with early RA were also collected. ACPA were detected by ELISA on viral citrullinated peptides (VCP) derived from Epstein-Barr-virus nuclear antigen (EBNA)1 and EBNA2 (VCP1 and VCP2) and histone-4-derived citrullinated peptides (HCP1 and HCP2). Results: In pre-symptomatic individuals vs. patients with early RA, anti-VCP1 antibodies were detected in 10.4 vs. 36.1 , anti-VCP2 in 17.1 vs. 52.3 Capecitabine , anti-HCP1 in 10.2 vs. 37.3 , and anti-HCP2 in 16.3 vs. 48.5 , respectively. Anti-VCP and anti-HCP concentrations were significantly increased in pre-symptomatic individuals vs. controls (p PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26217556 arthritis, a chronic inflammatory autoimmune disease, is a complex and multifactorial disorder influenced by both genetic and environmental factors [1]. A distinctive feature of RA is the presence of anticitrullinate-peptide antibodies (ACPA), i.e., autoantibodies* Correspondence: solbritt.rantapaa.dahlqvist@umu.se Linda Johansson and Federico Pratesi contributed equally and share first authorship. Paola Mig.